Jane L. Frederick, MD, FACOG

• Undergraduate: University of Southern California
• Medical School: University of Southern California
• Residency: Obstetrics and Gynecology Los Angeles County, University of Southern California Women’s Hospital
• Fellowship: Reproductive Endocrinology and Infertility Los Angeles County, University of Southern California Women’s Hospital

• Saddleback Memorial Medical Center
• Hoag Hospital, Newport Beach, CA

• Fellow, American College of Obstetricians and Gynecologists
• American Society of Reproductive Medicine
• Orange County Obstetrical and Gynecological Society
• Pacific Coast Reproductive Society, Past President
• Society of Assisted Reproductive Technology
• Society of Reproductive Endocrinology and Infertility

• Dr. Jane Frederick is an internationally noted specialist with a diverse clinical practice in reproductive surgery, IVF, and genetic screening of embryos.
• She has educated medical colleagues in the area of fertility preservation, and age and reproductive issues with numerous publications including The Couples Guide to In Vitro Fertilization and Trying To Conceive.

• Los Angeles Magazine – Top Women’s Health Doctor
• US News and World Report: top 10% Reproductive Endocrinologist
• Fertility Authority – Doctor of the Month
• Orange Coast Magazine – Top Doctor
• Castle Connolly Top Doctor
• Distinguished Service to Society, Pacific Coast Repro Society
• KNX News Radio Hero of the Year, 2017
• Founder, Jane L. Frederick, MD, FACOG Bonding Room, Saddleback Memorial Medical Center, 2012

Book Chapters

1. Frederick JL, Reproduction and Aging: When Your Biological Clock is Running Down. In: Young For Life, Birmingham, Alabama: Oxmoor House, Inc, 2004.

2. Frederick JL, The Couple’s Guide to In Vitro Fertilization, Cambridge, MA: Perseus Books Group, 2004.

3. Frederick JL, Women Doctors Guide to Health and Healing, Birmingham, Alabama: Oxmoor House, Inc., 2003.

4. Frederick JL Asch RH. Assisted Reproductive Technologies. In: Dooley MM, Brincat Multiparity, eds. Understanding Common Disorders in Reproductive Endocrinology, Chicester, England: John Wiley and Sons, 1994.

Journal Articles, Peer Reviewed

1. Johnson DS, Gemelos G, Baner J, Frederick JL, et al. Preclinical Validation of a Microarray Method for Full Molecular Karyotyping of Blastomeres in a 24-h Protocol. Human Reproduction 25(4): 1066-1075, 2010

2. Gonzales. S P, Maloul S, Ciuffardi I, Frederick JL, Balmaceda JP, Asch R. The use of progestins for programming assisted reproductive cycles and GmRH against flare up protocols in older patients. Fertil Steril 63(2): 249- 251, 1995.

3. Manzur A, Goldsman M, Stone SC, Frederick JL, Balmaceda JP, Asch RH. Outcome of triplet pregnancies following assisted reproductive techniques (ART): How frequent are the vanishing embryos? Fertil Steril 63(2): 252- 257, 1995.

4. Frederick JL, Marello E, Ord the, Kettel LM, Stone SC, Balmaceda JP, Asch RH. Successful pregnancy outcome after cryopreservation of all fresh embryos with subsequent transfer into an unstimulated cycle. Fertil Steril 64: 987-990, 1995.

5. Frederick JL, Ord the, Stone SC, Balmaceda JP, Asch RH. Frozen ZIFT: A successful approach for transfer of cryopreserved embryos. Fertil Steril 61(3): 504-507, 1994.

6. Schmidt LL, Asch RH, Frederick JL, Rojas FJ, Stone SC, Balmaceda JP. The predictive value of a single beta human chorionic gonadotropin in pregnancies achieved by assisted reproductive technology. Fertil Steril 62(2): 333-338, 1994.

7. Araujo Jr E, Bernardini L, Frederick JL, Asch RH, Balmaceda JP. A prospective randomized comparison of human chorionic gonadotropin vs. intramuscular progesterone for luteal phase support in assisted reproduction. J Asst Reprod Genet 11(2): 74-78, 1994.

8. Frederick JL, Denker MS, Rojas A, Horta I, Stone SC, Balmaceda JP, Asch RH. Is there a role for Ovarian Stimulation and Intrauterine Insemination after age 40? Hum Reprod 9(12): 2284-2286, 1994.

9. Ash RH, Ivery G, Goldsman M, Frederick JL, Stone SC, Balmaceda JP. The use of intravenous albumin in patients at high risk for severe ovarian hyperstimulation syndrome. Hum Reprod 8(7): 1015-1020, 1993.

10. Frederick JL, Francis MM, Macaso TM, Lobo RA, Sauer MV, Paulson RJ. Preovulatory follicular fluid steroid levels in stimulated and unstimulated cycles triggered with hCG. Fertil Steril 55 (1): 44-47, 1991.

11. Frederick JL, Hickey MJ, Francis MM, Paulson RJ. The effect of Leuprolide Acetate on steroidogenesis by granulosa and theca cells in vitro. J In Vitro Em 8(4): 230-234, 1991.

12. Frederick JL, Paulson RJ, Sauer MV. Routine use of vaginal ultrasound in the preoperative evaluation of gynecologic patients: An adjunct to resident education. J Reprod Medial 36 (11): 779-782, 1991.

13. Sauer MV, Paulson RJ, Frederick JL, Chenette PE, Stancyzk FZ. Effect of hydration on random levels of urinary pregnanediol glucuronide. Gynecol Endocrinol 4:145, 1990.

14. Frederick JL, Chenette PE, Paulson RJ, Stanczyk FZ, Sauer MV. Random urinary pregnanediol glucuronide (PDG) measurements in pregnancy: lack of utility for evaluation of first trimester vaginal bleeding. Hum Reprod 5 (4): 468-470, 1990.

15. Frederick JL, Hoa N, Preston DS, Frederick JJ, Campeau JD, Ono T. diZerega GS. Initiation of angiogenesis by porcine follicular fluid. Am J Obstetrical Gynecol 152 (8): 1073-1078, 1985.

16. Frederick JL, Shimanuki the. DiZerega GS. Initiation of angiogenesis by human follicular fluid. Science 224:389, 1984.

Journal Articles, Other

1. Frederick JL, Ord the, SC, Balmaceda JP, Asch RH. Frozen ZIFT: A successful approach for transfer of cryopreserved embryos. Obstetrical and Gynecological Survey 49:556-557, 1994.

2. Frederick JL, Denker MS, Rojas A, Horta I, Stone SC, Asch RH, Balmaceda JP. Is there a role for ovarian stimulation and intra-uterine insemination after age 40? Obstetrical and Gynecological Survey 50: 604-605, 1995.

3. Frederick JL, Denker MS, Rojas A, Horta I, Stone SC, Balmaceda JP, Asch RH. Controlled Ovarian Hyperstimulation (COH) and Intrauterine Insemination (IUI) in women 40 years of age and over. 1996 Yearbook of Obstetrics and Gynecology. St. Louis: Mosby

Abstracts and Posters

1. C. Khoury MSc, M Coffler, MD, J Frederick MD, D Potter MD. “Pre-Implantation Genetic Screening (PGS) with Trophectoderm Biopsy (TB) following Embryo Cleavage Biopsy. – A Case Series. 59th Pacific Coast Reproductive Society Annual Meeting, Indian Wells, CA 2011.

2. C. Khoury MSc, J Frederick, MD, M Coffler MD , D. Johnson, D Karabinus, D Potter MD. “Pre-implantation Genetic Screening: Aneuploid incidence with and without MicroSort sperm separation.” 66th American Society for Reproductive Medicine, Denver, CO 2010.

3. C. Khoury MSc, B Behr, J Frederick, MD, D Potter MD. “Pre-implantation Genetic Screening (PGS) for aneuploidy using 24 Chromosome Parental Support Technology.” 58th Pacific Coast Reproductive Society Annual Meeting, Indian Wells, CA 2010.

4. C. Khoury MSc, B Behr, D Potter MD, J Frederick MD. “Pregnancy results on frozen blastocyst transfer created from fresh IVF cycles with PGS.” 58th Pacific Coast Reproductive Society Annual Meeting, Indian Wells, CA 2010.

5. C. Khoury MSc, J Frederick MD, B Behr, D Potter MD. “A comparison of blastocyst slow freeze and vitrification in frozen blastocyst transfer.” 57th Pacific Coast Reproductive Society Annual Meeting, Indian Wells, CA 2009.

6. C. Khoury MSc, J Frederick MD, B Behr, D Potter MD. “Live birth of a healthy baby girl following the replacement of vitrified Day Six blastocyst after MicroSort.” – A Case Report. 57th Pacific Coast Reproductive Society Annual Meeting, Indian Wells, CA 2009.

7. C. Khoury MSc, J Frederick MD, B Behr PhD, D Potter MD. “Ongoing Clinical Pregnancy with Transport Vitrified Blastocyst.” Abstract published in the online Abstract Supplement to Fertility and Sterility, A-13.

8. C. Khoury MSc, J Frederick MD, B Behr PhD, D Potter MD. “Is oocyte freezing an option to couples who choose to inseminate fewer oocytes for ethical reasons?” – A case report. Abstract publish in the online Abstract Supplement to Fertility and Sterility, A-129.

9. C. Khoury MSc, B Behr PhD., D Potter MD, J Frederick MD. “Comparison between day three transfer and day five transfer over a period of six years”. 56th Pacific Coast Reproductive Society Annual Meeting, 2008, Indian Wells, CA.

10. C. Khoury MSc, D. Potter MD, J Frederick MD, B Behr PhD. “Comparison of blastocyst transfer with and without pre-implantation genetic screening in both IVF patients and oocyte donors”. 56th Pacific Coast Reproductive Society Annual Meeting, 2008, Indian Wells, CA

11. C. Khoury MSc, J Frederick MD., D. Potter MD, B Bher PhD. “Live birth of a normal healthy baby following replacement of refrozen blastocysts; previously thawed, hatched on day three and cultured to the blastocyst stage then refrozen”. 63rd Annual Meeting of the American Society for Reproductive Medicine October 13-17, 2007 Washington, DC.

12. Khoury C, Frederick JL, Behr B. Successful pregnancy with the exclusive use of frozen gametes. 55th Annual Meeting of the Pacific Coast Reproductive Society, Rancho Mirage, CA, April 2007.

13. C. Khoury MSc, J. Frederick, DA Potter, B Behr. “Extended post-thaw culture is an efficient way to reduce the number of frozen embryos in storage”. 54th Pacific Coast Reproductive Society Annual Meeting, 2006, Indian Wells, CA

14. Khoury C, Frederick JL, Potter D, Behr B. Extended post-thaw culture is an efficient way to reduce the cost of frozen embryo transfer. 62nd Annual Meeting of the American Society of Reproductive Medicine, New Orleans, LA, October 2006.

15. Nelson J, Potter D, Wilcox J, Frederick JL, Kolb B, Behr B. Preimplantation Genetic Diagnosis in embryos created from oocyte donation. 61st Annual Meeting of the American Society of Reproductive Medicine, Montreal, Quebec, Canada, October 2005.

16. Behr B, Le A, Wang H, Khoury C, Boostanfar B, Feinman M, Frederick JL. Comparison between two different human oocyte cryopreservation protocols on survival, fertilization, and embryo development. 61st Annual Meeting of the American Society of Reproductive Medicine, Montreal, Quebec, Canada, October 2005.

17. Potter D. Khoury C, Feinman M, Frederick JL, Behr B. Extended post-thaw culture improved frozen embryo transfer success rates. 21st Annual Meeting of the European Society of Human Reproduction and Embryology. Copenhagen, Denmark, June 2005.

18. Wilcox J, Nelson J, Potter D, Frederick JL, Feinman M, Balzofin J. Comparison of the different luteal phase support protocols for frozen embryo transfer (FET) 57th Annual Meeting of the American Society of Reproductive Medicine, Orlando, Florida, October 2001.

19. Frederick JL, Balmaceda JP, Asch RH. Successful pregnancy outcome with oocyte donation in patients with Turner’s syndrome. 50th Annual Meeting of the American Fertility Society, San Antonio, TX, November 5-10, 1994.

20. Ciuffardi I, Bernardini L, Goldsman M, Frederick JL, Asch RH, Balmaceda JP. Age and uterine receptivity: oocyte donation model results. 42nd Annual Meeting of the Pacific Coast Fertility Society, Indian Wells, California, April 20-24, 1994.

21. Frederick JL, Ciuffardi I, Snell K, Ord the, Balmaceda JP, Asch RH. Embryo implantation rates in oocyte donation. 50th Annual Meeting of the American Fertility Society, San Antonio, TX, November 5-10, 1994.

22. Gonzales-Suau P, Maloul S, Ciuffardi I, Frederick JL, Balmaceda JP, Asch RH. Progestin administration for synchronization or ART cycles does not interfere with ovarian response to GnRH agonist flare up protocols. 42nd Annual Meeting of the Pacific Coast Fertility Society, Indian Wells, California, April 20-24, 1994.

23. Manzur A, Goldsman M, Stone SC, Frederick JL, Balmaceda JP, Asch RH. Outcome of triplet pregnancies following assisted reproductive techniques (ART). How frequent are the vanishing embryos? 42nd Annual Meeting of the Pacific Coast Fertility Society, Indian Wells, California, April 20-24, 1994.

24. Frederick JL, Ciuffardi I, Snell K, Ord the, Balmaceda JP, Asch RH. Oocyte donation: A prospective comparison of GIFT vs IVF. 42nd Annual Meeting of the Pacific Coast Fertility Society, Indian Wells, California, April 20-24, 1994.

25. Frederick JL, Marello E, Ord the, Stone SC, Balmaceda JP, Asch Rh. Successful pregnancy outcome after cryopreservation of all fresh embryos with subsequent transfer into an unstimulated cycle. 42nd Annual Meeting of the Pacific Coast Fertility Society, Indian Wells, California, April 20-24, 1994.

26. Frederick JL, Manzur A, Balmaceda JP, Stone SC, Asch RH. Is follicle stimulating hormone “(FSH) alone” an effective alternative for ovulation induction in the poor responder patient? 42nd Annual Meeting of the Pacific Coast Fertility Society, Indian Wells, California, April 20-24, 1994.

27. Felix C, Bernardini L, Araujo Jr E, Ord the, Asch RH, Frederick JL, Balmaceda JP. Fresh vs frozen uterine transfers in an oocyte donation program. 41st Annual Meeting of the Pacific Coast Fertility Society, Indian Wells, California, April 14-18, 1993.

28. Frederick JL, Vicino M, Ord the, Stone SC, Balmaceda JP, Asch RH. Frozen ZIFT: A successful approach for transfer of cryopreserved embryos. 41st Annual Meeting of the Pacific Coast Fertility Society, Indian Wells, California, April 14-18, 1993.

29. Schmidt LL, Asch RH, Frederick JL, Rojas FJ, Stone SC, Balmaceda JP. The predictive value of a single BhCG in pregnancies achieved by Assisted Reproductive Technology. 41st Annual Meeting of the Pacific Coast Fertility Society, Indian Wells, California, April 14-18, 1993. Paper and primary author given Serono In-Training Award.

30. Araujo Jr E, Felix C, Bernardini L, Stone S, Frederick JL, Asch RH, Balmaceda JP. Luteal phase support for Assisted Reproductive Technology: A prospective, randomized study of Human Chorionic Gonadotropin versus Intramuscular Progesterone. 41st Annual Meeting of the Pacific Coast Fertility Society, Indian Wells, California, April 14-18, 1993.

31. Horta I, Rojas A, Stone SC, Balmaceda JP, Frederick JL, Asch RH. Superovulation and intrauterine insemination: Comparison of results according to women’s age. XIV World Congress on Fertility and Sterility, Caracas Venezuela, November 22-27, 1992.

32. Asch RH, Ivery G, Stone SC, Frederick JL, Balmaceda JP. Albumin prophylaxis for the development of severe hyperstimulation syndrome in ART cycles. XIV World Congress on Fertility and Sterility, Caracas, Venezuela, November 22-27, 1992.

33. Gonzalez J, Ord the, Marcello E, Asch RH, Frederick JL, Stone SC, Balmaceda JP. Natural cycle and hormonal replacement in FET: Implantation and pregnancy rates. 48th Annual Meeting of The American Fertility Society, New Orleans, Louisiana, October 31 – November 5, 1992.

34. Balmaceda JP, Bernardini L, Gonzalez J, Frederick JL, Stone S, Ord the, Asch RH. Evidence that controlled ovarian hyperstimulation is not detrimental to the outcome of IVF-EF GIFT or ZIFT. 48th Annual Meeting of The American Fertility Society, New Orleans, Louisiana, October 31 – November 5, 1992.

35. Frederick JL, Paulson RJ, Sauer MV, Francis MM, Macaso TM, Lobo RA. Preovulatory follicular fluid steroid levels in stimulated and unstimulated cycles triggered with HCG. 38th Annual Meeting of the Pacific Coast Fertility Society, Scottsdale, Arizona, 1990.

36. Frederick JL, Chenette PE, Paulson RJ, Stanczyk FZ, Sauer MV. Clinical Utility of random urinary pregnanediol glucuronide (PDG) measurements in the evaluation of first trimester vaginal bleeding. 45th Annual Meeting of The American Fertility Society, San Francisco, California, 1989.

37. Frederick JL, Hickey MJ, Francis MM, Paulson RJ. The effect of Leuprolide Acetate on steroidogenesis by granulosa and theca cells in vitro. 45th Annual Meeting of The American Fertility Society, San Francisco, California, 1989.

38. Frederick JL, Paulson RJ, Sauer MV. Comparison of vaginosonography and bimanual pelvic examination in preoperative assessment of gynecologic patients. Second World Congress on Vaginosonography in Gynecology, American Association of Gynecologic Laparoscopists, Annual Meeting, San Francisco, California, 1989.

39. Frederick JL, Francis MM, Macaso TM, Paulson RJ. The effect of Leuprolide Acetate on hCG stimulated granulosa cell steroidogenesis in vitro. 37th Annual Meeting of the Pacific Coast Fertility Society, Palm Springs, California, 1989.

40. Frederick JL, Shimanuki T., diZerega GS. Initiation of angiogenesis by human follicular fluid. 31st Annual Meeting, Society for Gynecology Investigation, San Francisco, California, 1984.

41. Frederick JL, Barndt R. The effect of Psychobiological factors upon the extent of experimental atherosclerosis. Annual Meeting, American Federation for Clinical Research, Carmel, California, 1980.

• Quoted: Fertility diet: what to eat when you’re trying to get pregnant 
• Quoted: This may be the best time of day to get pregnant
• Quoted: Do men have biological clocks? It’s not just women who have to worry about age and fertility, experts say.
• Quoted: The Ins and Outs of Fertility Benefits: How Employers Can Attract Talent and Strengthen Employee Relationships
• Quoted: How the Roe v. Wade decision puts fertility care at risk 
• Quoted: Air Force vet who battled tough fertility issue tells others, ‘Knowledge is power’
• Quoted: IVF treatment evolves to ‘open up doors’ for more diverse patient population
• Quoted: Are fertility benefits a right or a privilege? An infertility specialist weighs in
• Quoted: Here Come the Holidays! Friends, Family and Fertility Questions
• Perspective: Controversial embryo screening method improves live birth rates
• Quoted: Everyday Habits That Shorten Your Life, According to Science
• Podcast: COVID and the Menstrual Cycle 
• Quoted: Bleeding between periods can be a sign of ovulation or something more serious
• Perspective: Better timing with flu vaccination campaigns could protect more pregnant women, babies
• Quoted: The Best Pregnancy Tests Available At Your Local Store
• Quoted: How Egg Freezing Can Support Cancer Survivors on Their Paths to Parenthood
• Quoted: Why experts are calling out ESPN’s Allison Williams for her COVID-19 vaccine and fertility statement
• Quoted: When To Announce Your Pregnancy
• Quoted: Recent Advances in Infertility Treatment
• Quoted: How Does Sperm Morphology Affect Fertility?
• Quoted: www.enterprisersuite.com
• Blogs: The Infertility Game Plan for the Holidays
• Book: Frederick, Jane L. Trying to Conceive, 2015 
• Quoted: MSN.com, “5 Things You Can Do For Your Fertility During the Pandemic”
• Feature Article: “When a Pregnancy Fails, Surrogacy is a Second Chance,” OC Family Magazine, May 2020
• Feature Interview: “Newport Doctor Offers Infertility Options During Men’s Health Month,” Newport Independent, June 2020
• Feature Interview: “Everything to Know About Endometriosis: An Interview with Dr. Jane Frederick”
• Quoted: Greatist.com, “Low Sperm Count? 15 Ways to Get Olympic-Level Swimmers“
• Quoted: We Asked Health Experts To Break Down How Stress Can Impact Nearly Every Part of the Body

YOUTUBE VIDEOS:

• Fertility 101 with Dr. Jane Frederick
• Dr. Jane Frederick:  What To Know About Freezing Eggs
• https://youtu.be/BfOlusJsHQ0
• https://youtu.be/3H83r3Rjz_g
• https://youtu.be/ayrSnelvrGM
• https://youtu.be/jhYLlQV04pM
• https://youtu.be/-UdVVVEMyp4